Human papillomavirus infection and bladder cancer risk: a meta-analysis.

ABSTRACT:

Background

Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the association between human papillomavirus (HPV) infection and risk of bladder cancer, the studies remain inconclusive.

Methods

The prevalence of HPV in bladder cancer was estimated by pooling data from 52 studies, taking into consideration the heterogeneity from major related parameters including study region, histological type, HPV DNA specimen, publication calendar period, and detection method. Moreover, the association of HPV infection with bladder cancer was tested by a meta-analysis with 19 case-control studies.

Results

An HPV prevalence of 16.88% (95% confidence interval [CI], 15.53%-18.31%) among the bladder cancer cases was revealed, most

SUBMITTER: Li N 

PROVIDER: S-EPMC3114469 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature