Impact of natriuretic peptide clearance receptor (NPR3) gene variants on blood pressure in type 2 diabetes.

ABSTRACT:

Objective

Hypertension in diabetes is characterized by abnormal sodium homeostasis, suggesting a particular role of natriuretic peptide pathway. Natriuretic peptides can affect blood pressure (BP) through their plasma concentrations, which are dependent on their receptor activities. We thus assessed the association between nine NPR3 gene polymorphisms and BP levels in patients with type 2 diabetes.

Research design and methods

Nine single nucleotide polymorphisms (SNPs) tagging the haplotype structure of the NPR3 gene were genotyped in the 3,126 French Non-insulin-dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) trial participants. We then used a second population (Diabete de type 2, Nephropathie et Genetique [

SUBMITTER: Saulnier PJ 

PROVIDER: S-EPMC3114497 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature