Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder.

ABSTRACT:

Objective

Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established.

Method

This was a case-control genetic association study of HTT CAG allele size in two discovery cohorts of individuals with major depressive disorder and comparison subjects without major depression as well as a replication cohort of individuals with major depression and comparison subjects without major depression.

Results

CAG repeat lengths of 36 or greater were observed in six of 3,054 chromosomes from individuals with major depre

SUBMITTER: Perlis RH 

PROVIDER: S-EPMC3114558 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature