Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases.

ABSTRACT:

Background

Scientists have been trying to understand the molecular mechanisms of diseases to design preventive and therapeutic strategies for a long time. For some diseases, it has become evident that it is not enough to obtain a catalogue of the disease-related genes but to uncover how disruptions of molecular networks in the cell give rise to disease phenotypes. Moreover, with the unprecedented wealth of information available, even obtaining such catalogue is extremely difficult.

Principal findings

We developed a comprehensive gene-disease association database by integrating associations from several sources that cover different biomedical aspects of diseases. In particular, we focus on the current knowledge of human genetic diseases including mendelian, complex and enviro

SUBMITTER: Bauer-Mehren A 

PROVIDER: S-EPMC3114846 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature