Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.

ABSTRACT:

Background

The Duffy-null trait and ethnic netropenia are both highly prevalent in Africa. The influence of pre-seroconversion levels of peripheral blood cell counts (PBCs) on the risk of acquiring human immunodeficiency virus (HIV)-1 infection among Africans is unknown.

Methods

The triangular relationship among pre-seroconversion PBC counts, host genotypes, and risk of HIV acquisition was determined in a prospective cohort of black South African high-risk female sex workers. Twenty-seven women had seroconversion during follow-up, and 115 remained HIV negative for 2 years, despite engaging in high-risk activity.

Results

Pre-seroconversion neutrophil counts in women who subsequently had seroconversion were significantly lower, whereas platelet counts were higher, compa

SUBMITTER: Ramsuran V 

PROVIDER: S-EPMC3115278 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature