Exposure to the Endocrine Disruptor Bisphenol A Alters Susceptibility for Mammary Cancer.

ABSTRACT: Bisphenol A (BPA) is a synthetically made chemical used in the production of polycarbonate plastics and epoxy resins. Recent studies have shown over ninety percent of humans investigated have detectable BPA concentrations. Yet, the biggest concern for BPA is exposure during early development because BPA has been shown to bind to the estrogen receptors (ER) and cause developmental and reproductive toxicity. We have investigated the potential of perinatal BPA to alter susceptibility for chemically-induced mammary cancer in rats. We demonstrate that prepubertal exposure to low concentrations of orally administered BPA given to lactating dams resulted in a significantly decreased tumor latency and increased tumor multiplicity in the dimethylbenz[a]anthracene (DMBA) model of rodent mammary carc

SUBMITTER: Lamartiniere CA 

PROVIDER: S-EPMC3115692 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature