Identification and classification of acute cardiac rejection by intragraft transcriptional profiling.

ABSTRACT:

Background

Treatment of acute rejection (AR) in heart transplantation relies on histopathological grading of endomyocardial biopsies according to International Society for Heart and Lung Transplantation guidelines. Intragraft gene expression profiling may be a way to complement histological evaluation.

Methods and results

Transcriptional profiling was performed on 26 endomyocardial biopsies, and expression patterns were compared with the 1990 International Society for Heart and Lung Transplantation AR grades. Importantly, transcriptional profiles from settings with an equivalent AR grade appeared the same. In addition, grade 0 profiles could not be distinguished from 1A profiles, and grade 3A profiles could not be distinguished from 3B profiles. Comparing the AR groupings (0

SUBMITTER: Holweg CT 

PROVIDER: S-EPMC3115694 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature