MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis.

ABSTRACT:

Background

The tumor suppressor gene p53 is involved in multiple cellular pathways including apoptosis, transcriptional control, and cell cycle regulation. In the last decade it has been demonstrated that the single nucleotide polymorphism (SNP) at codon 72 of the p53 gene is associated with the risk for development of various neoplasms. MDM2 SNP309 is a single nucleotide T to G polymorphism located in the MDM2 gene promoter. From the time that this well-characterized functional polymorphism was identified, a variety of case-control studies have been published that investigate the possible association between MDM2 SNP309 and cancer risk. However, the results of the published studies, as well as the subsequent meta-analyses, remain contradictory.

Methods

To investigate whethe

SUBMITTER: Wan Y 

PROVIDER: S-EPMC3115916 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature