Strategic approaches to unraveling genetic causes of cardiovascular diseases.

ABSTRACT: DNA sequence variants are major components of the "causal field" for virtually all medical phenotypes, whether single gene familial disorders or complex traits without a clear familial aggregation. The causal variants in single gene disorders are necessary and sufficient to impart large effects. In contrast, complex traits are attributable to a much more complicated network of contributory components that in aggregate increase the probability of disease. The conventional approach to identification of the causal variants for single gene disorders is genetic linkage. However, it does not offer sufficient resolution to map the causal genes in small families or sporadic cases. The approach to genetic studies of complex traits entails candidate gene or genome-wide association studies. Genome-wi

SUBMITTER: Marian AJ 

PROVIDER: S-EPMC3115927 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature