Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence.

ABSTRACT:

Background

Depressive symptoms are common among individuals with alcohol use disorders and impact treatment outcome. Substantial overlap exists among the neurobiological systems proposed in the pathophysiology of depressive and alcohol use disorders; however, specific genetic effects contributing to risk for depressive comorbidity remain poorly understood.

Methods

This study examines the association of depressive symptom scores for lifetime depression (the sum of DSM-IV major depression co-endorsed criteria for lifetime depression) with markers in 120 candidate genes in 554 alcohol-dependent individuals. The candidate genes code for molecules involved in dopamine, serotonin, glutamate, gamma-aminobutyric acid (GABA), and opioid neurotransmission, cell signaling, pharmacokine

SUBMITTER: Kertes DA 

PROVIDER: S-EPMC3116055 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature