Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target.

ABSTRACT:

Background

The role of microRNAs (miRNAs) in regulating gene expression is currently an area of intense interest. Relatively little is known, however, about the role of miRNAs in inflammatory and immunologically-driven disorders. In a mouse model, we have previously shown that miRNAs are potentially important therapeutic targets in allergic asthma, because inhibition of miR-126, one of a small subset of miRNAs upregulated in the airway wall, effectively suppressed Th2-driven airway inflammation and other features of asthma. In the present study, we extended investigation of the therapeutic potential of miRNA inhibition to our well-established model of chronic asthma.

Methods

Female BALB/c mice were systemically sensitised with ovalbumin (OVA) and chronically challenged with

SUBMITTER: Collison A 

PROVIDER: S-EPMC3116478 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature