A hidden two-locus disease association pattern in genome-wide association studies.

ABSTRACT:

Background

Recent association analyses in genome-wide association studies (GWAS) mainly focus on single-locus association tests (marginal tests) and two-locus interaction detections. These analysis methods have provided strong evidence of associations between genetics variances and complex diseases. However, there exists a type of association pattern, which often occurs within local regions in the genome and is unlikely to be detected by either marginal tests or interaction tests. This association pattern involves a group of correlated single-nucleotide polymorphisms (SNPs). The correlation among SNPs can lead to weak marginal effects and the interaction does not play a role in this association pattern. This phenomenon is due to the existence of unfaithfulness: the marginal effects

SUBMITTER: Yang C 

PROVIDER: S-EPMC3116488 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature