Transcriptional double-autorepression feedforward circuits act for multicellularity and nervous system development.

ABSTRACT:

Background

The transcriptional regulatory network is considered to be built from a set of circuit patterns called network motifs. Experimental studies have provided instances where a feedforward circuit (FFC) appears with modification of autoregulation, but little is known systematically about such autoregulation-integrated FFCs. Therefore, we aimed to examine whether the autoregulation-integrated FFC is a network motif relevant to describing the human transcriptional regulatory systems, and explored the relationship of such network motifs with biological functions.

Results

Based on human-mouse evolutionarily conserved transcription factor binding sites (TFBSs) in 76600 conserved blocks for 5169 genes, we compiled the human transcriptional connections into a matrix, and exam

SUBMITTER: Iwama H 

PROVIDER: S-EPMC3116505 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature