RhoGDI3 and RhoG: Vesicular trafficking and interactions with the Sec3 Exocyst subunit.

ABSTRACT: RhoGDIs are negative regulators of small GTP-binding proteins of the Rho family, which have essential cellular functions in most aspects of actin-based morphology and motility processes. They extract Rho proteins from membranes, keep them in inactive rhoGDI/Rho complexes and eventually deliver them again to specific membranes in response to cellular signals. RhoGDI3, the most divergent member of the rhoGDI family, is well suited to document the underlying molecular mechanisms, since the active and inactive forms of its cellular target, RhoG, have well-separated subcellular localizations. In this study, we investigate trafficking structures and molecular interactions involved in rhoGDI3-mediated shuttling of RhoG between the Golgi and the plasma membrane.Bimolecular fluorescence complementa

SUBMITTER: Morin A 

PROVIDER: S-EPMC3116606 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature