Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism.

ABSTRACT:

Background

Causes of autism are unknown. Associations with maternal nutritional factors and their interactions with gene variants have not been reported.

Methods

Northern California families were enrolled from 2003 to 2009 in the CHARGE (CHildhood Autism Risks from Genetics and Environment) population-based case-control study. Children aged 24-60 months were evaluated and confirmed to have autism (n = 288), autism spectrum disorder (n = 141), or typical development (n = 278) at the University of California-Davis Medical Investigation of Neurodevelopmental Disorders Institute using standardized clinical assessments. We calculated adjusted odds ratios (ORs) for associations between autism and retrospectively collected data on maternal vitamin intake before and during pregnancy

SUBMITTER: Schmidt RJ 

PROVIDER: S-EPMC3116691 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature