Generation of diverse biological forms through combinatorial interactions between tissue polarity and growth.

ABSTRACT: A major problem in biology is to understand how complex tissue shapes may arise through growth. In many cases this process involves preferential growth along particular orientations raising the question of how these orientations are specified. One view is that orientations are specified through stresses in the tissue (axiality-based system). Another possibility is that orientations can be specified independently of stresses through molecular signalling (polarity-based system). The axiality-based system has recently been explored through computational modelling. Here we develop and apply a polarity-based system which we call the Growing Polarised Tissue (GPT) framework. Tissue is treated as a continuous material within which regionally expressed factors under genetic control may interact an

SUBMITTER: Kennaway R 

PROVIDER: S-EPMC3116900 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature