Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.

ABSTRACT:

Background and aims

Macronutrient intakes and genetic variants have been shown to interact to alter insulin resistance, but replications of gene-nutrient interactions across independent populations are rare, despite their critical importance in establishing credibility. We aimed to investigate a previously demonstrated saturated fat and carbohydrate interaction for insulin resistance for perilipin (PLIN1), a regulator of adipocyte metabolism.

Methods and results

We investigated the previously shown interaction for PLIN1 11482G > A (rs894160) on insulin resistance in US men (n = 462) and women (n = 508) (mean ± SD, 49 ± 16 years). In multivariable linear regression models, we found an interaction (P < 0.05) between the ratio of saturated fat to carbohydrate intake as a contin

SUBMITTER: Smith CE 

PROVIDER: S-EPMC3117106 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature