Changes in lipids and lipoprotein particle concentrations after interruption of antiretroviral therapy.

ABSTRACT:

Background

The effect of interruption of antiretroviral therapy (ART) on lipoprotein particle subclasses has not been studied. We examined short-term changes in lipids and lipoprotein particles among 332 HIV-infected individuals randomized to interrupt or continue ART in the "Strategies for Management of Antiretroviral Therapy" trial.

Methods

Lipids and lipoprotein particles measured by nuclear magnetic resonance spectroscopy were compared between randomized groups at month 1; associations with inflammatory and coagulation markers (high sensitivity C-reactive protein; interleukin 6; amyloid A; amyloid P; D-dimer; prothrombin fragment 1 + 2) were assessed.

Results

Compared with continuation of ART, treatment interruption resulted in substantial declines in total, low-d

SUBMITTER: Lampe FC 

PROVIDER: S-EPMC3117147 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature