Theoretical and computational investigation of flagellin translocation and bacterial flagellum growth.

ABSTRACT: The bacterial flagellum is a self-assembling filament, which bacteria use for swimming. It is built from tens of thousands of flagellin monomers in a self-assembly process that involves translocation of the monomers through the flagellar interior, a channel, to the growing tip. Flagellum monomers are pumped into the filament at the base, move unfolded along the channel and then bind to the tip of the filament, thereby extending the growing flagellum. The flagellin translocation process, due to the flagellum maximum length of 20 μm, is an extreme example of protein transport through channels. Here, we derive a model for flagellin transport through the long confining channel, testing the key assumptions of the model through molecular dynamics simulations that also furnish system parameters n

SUBMITTER: Tanner DE 

PROVIDER: S-EPMC3117181 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature