Dataset Information
BINOCh: binding inference from nucleosome occupancy changes.
Ontology highlight
ABSTRACT: Unlabelled
Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy, while those in the vicinity of the binding site itself are displaced. Genome-wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer-related histone modifications such as H3K4me2. Here, we present a software package, BINOCh that allows biologists to use such data to infer the identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation.Availability
The BINOCh open source Python package is freely available at http://liulab.dfci.harvard.edu/BINOCh under the FreeBSD license.
SUBMITTER: Meyer CA
PROVIDER: S-EPMC3117357 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
BINOCh: binding inference from nucleosome occupancy changes.
Bioinformatics (Oxford, England) 20110505 13
<h4>Unlabelled</h4>Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy, while those in the vicinity of the binding site itself are displaced. Genome-wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer-related histone modifications such as H3K4me2. Here, we present a software package, BINOCh that allows biolo ...[more]