Health status in the TORCH study of COPD: treatment efficacy and other determinants of change.

ABSTRACT:

Background

Little is known about factors that determine health status decline in clinical trials of COPD.

Objectives

To examine health status changes over 3 years in the TORCH study of salmeterol+fluticasone propionate (SFC) vs. salmeterol alone, fluticasone propionate alone or placebo.

Methods

St George's Respiratory Questionnaire (SGRQ) was administered at baseline then every 6 months.

Measurements and main results

Data from 4951 patients in 28 countries were available. SFC produced significant improvements over placebo in all three SGRQ domains during the study: (Symptoms -3.6 [95% CI -4.8, -2.4], Activity -2.8 [95% CI -3.9, -1.6], Impacts -3.2 [95% CI -4.3, -2.1]) but the pattern of change over time differed between domains. SGRQ deteriorated faster in pati

SUBMITTER: Jones PW 

PROVIDER: S-EPMC3117702 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature