Evolutionary plasticity determination by orthologous groups distribution.

ABSTRACT:

Background

Genetic plasticity may be understood as the ability of a functional gene network to tolerate alterations in its components or structure. Usually, the studies involving gene modifications in the course of the evolution are concerned to nucleotide sequence alterations in closely related species. However, the analysis of large scale data about the distribution of gene families in non-exclusively closely related species can provide insights on how plastic or how conserved a given gene family is. Here, we analyze the abundance and diversity of all Eukaryotic Clusters of Orthologous Groups (KOG) present in STRING database, resulting in a total of 4,850 KOGs. This dataset comprises 481,421 proteins distributed among 55 eukaryotes.

Results

We propose an index to evaluate

SUBMITTER: Dalmolin RJ 

PROVIDER: S-EPMC3117832 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature