Immunological and molecular epidemiological characteristics of acute and fulminant viral hepatitis A.

ABSTRACT:

Background

Hepatitis A virus is an infection of liver; it is hyperendemic in vast areas of the world including India. In most cases it causes an acute self limited illness but rarely fulminant. There is growing concern about change in pattern from asymptomatic childhood infection to an increased incidence of symptomatic disease in the adult population.

Objective

In-depth analysis of immunological, viral quantification and genotype of acute and fulminant hepatitis A virus.

Methods

Serum samples obtained from 1009 cases of suspected acute viral hepatitis was employed for different biochemical and serological examination. RNA was extracted from blood serum, reverse transcribed into cDNA and amplified using nested PCR for viral quantification, sequencing and genotyping. I

SUBMITTER: Hussain Z 

PROVIDER: S-EPMC3117845 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature