Eukaryotic protein kinases (ePKs) of the helminth parasite Schistosoma mansoni.

ABSTRACT:

Background

Schistosomiasis remains an important parasitic disease and a major economic problem in many countries. The Schistosoma mansoni genome and predicted proteome sequences were recently published providing the opportunity to identify new drug candidates. Eukaryotic protein kinases (ePKs) play a central role in mediating signal transduction through complex networks and are considered druggable targets from the medical and chemical viewpoints. Our work aimed at analyzing the S. mansoni predicted proteome in order to identify and classify all ePKs of this parasite through combined computational approaches. Functional annotation was performed mainly to yield insights into the parasite signaling processes relevant to its complex lifestyle and to select some ePKs as potential drug

SUBMITTER: Andrade LF 

PROVIDER: S-EPMC3117856 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature