Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity.

ABSTRACT:

Background

The endocannabinoid system is associated with food intake. We hypothesized that genes regulating cannabinoids are associated with obesity. Genetic variations in fatty acid amide hydroxylase (FAAH) and cannabinoid receptor 1 (CNR1) are associated with satiation and gastric motor function.

Methods

In 62 overweight or obese adults of European ancestry, single nucleotide polymorphisms of rs806378 (nearest gene CNR1) and rs324420 (nearest gene FAAH) were genotyped and the associations with gastric emptying (GE) of solids and liquids, gastric volume (GV), and satiation [maximum tolerated volume (MTV) and symptoms after Ensure(®) nutrient drink test] were explored using a dominant genetic model, with gender and BMI as covariates.

Key results

rs806378 CC genotype w

SUBMITTER: Vazquez-Roque MI 

PROVIDER: S-EPMC3117918 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature