Citalopram improves metabolic risk factors among high hostile adults: results of a placebo-controlled intervention.

ABSTRACT: Hostility is associated with a number of metabolic risk factors for cardiovascular disease, including waist-hip ratio, glucose, and triglycerides. Along with hostility, many of these measures have also been shown to be associated with reduced central serotonergic function. We have previously reported that a citalopram intervention was successful in reducing hostility by self-report assessment (Kamarck et al., 2009). Here we examine the effects of this serotonergic intervention on metabolic risk factors in the same sample. 159 healthy adults with elevated hostility scores were randomized to citalopram or placebo for a 2-month period. Citalopram favorably changed metabolic risk factors, including waist circumference (p=.003), glucose (p=.02), HDL cholesterol (p=.04), triglycerides (p=.03), i

SUBMITTER: Kamarck TW 

PROVIDER: S-EPMC3118402 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature