Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays.

ABSTRACT:

Background

Our previous studies revealed that a new disease form of streptococcal toxic shock syndrome (STSS) is associated with specific Streptococcus suis serotype 2 (SS2) strains. To achieve a better understanding of the pathogenicity and evolution of SS2 at the whole-genome level, comparative genomic analysis of 18 SS2 strains, selected on the basis of virulence and geographic origin, was performed using NimbleGen tiling arrays.

Results

Our results demonstrate that SS2 isolates have highly divergent genomes. The 89K pathogenicity island (PAI), which has been previously recognized as unique to the Chinese epidemic strains causing STSS, was partially included in some other virulent and avirulent strains. The ABC-type transport systems, encoded by 89K, were hypothesized to

SUBMITTER: Wu Z 

PROVIDER: S-EPMC3118785 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature