ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.

ABSTRACT:

Background

The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1).

Objective

We investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain.

Design

We undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from s

SUBMITTER: Morcillo S 

PROVIDER: S-EPMC3118791 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature