Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study.

ABSTRACT:

Background

Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded relationship to SCD, and 35% to 45% of its variation is heritable. We examined the relationship among recently reported common genetic variants, QT interval, and SCD.

Methods and results

We genotyped 15 common (minor allele frequency >1%) candidate single nucleotide polymorphisms (SNPs), based on association with the QT interval in prior studies, in individuals in 2 cohort studies (Health 2000, n = 6597; Mini-Finland, n = 801). After exclusions, we identified 116 incident SCDs from the remaining sample (n = 6808). We constructed a QT genotype score (QT(score)) using the allele copy number and previously reported effect esti

SUBMITTER: Noseworthy PA 

PROVIDER: S-EPMC3119024 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature