Ontology highlight
ABSTRACT:
SUBMITTER: Schoenfeld R
PROVIDER: S-EPMC3119038 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Schoenfeld Robert R Wong Alice A Silva Jillian J Li Ming M Itoh Aki A Horiuchi Makoto M Itoh Takayuki T Pleasure David D Cortopassi Gino G
Mitochondrion 20091222 2
Demyelination occurs in multiple inherited mitochondrial diseases. We studied which genes were induced as a consequence of differentiation in rodent and human oligodendroglia. Cholesterol, myelin and mitochondrial genes were significantly increased with oligodendroglial differentiation. Mitochondrial DNA content per cell and acetyl CoA-related transcripts increased significantly; thus, the large buildup of cholesterol necessary for myelination appears to require mitochondrial production of acety ...[more]