CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey.

ABSTRACT:

Background

CRP gene polymorphisms are associated with serum C-reactive protein concentrations and may play a role in chronic kidney disease (CKD) progression. We recently reported an association between the gene variant rs2808630 and CKD progression in African Americans with hypertensive kidney disease. This association has not been studied in other ethnic groups.

Methods

We used data from 5955 participants from Phase 2 of The Third National Health and Nutrition Examination Survey (1991-1994) to study the association between CRP polymorphisms and CKD prevalence in a population-based sample. The primary outcome was CKD defined as estimated glomerular filtration rate (eGFR) <60 ml/min or the presence of albuminuria. Secondary outcomes were the presence of albuminuria (any degr

SUBMITTER: Hung AM 

PROVIDER: S-EPMC3119179 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature