Cobinamide is superior to other treatments in a mouse model of cyanide poisoning.

ABSTRACT:

Context

Cyanide is a rapidly acting cellular poison, primarily targeting cytochrome c oxidase, and is a common occupational and residential toxin, mostly via smoke inhalation. Cyanide is also a potential weapon of mass destruction, with recent credible threats of attacks focusing the need for better treatments, as current cyanide antidotes are limited and impractical for rapid deployment in mass casualty settings.

Objective

We have used mouse models of cyanide poisoning to compare the efficacy of cobinamide (Cbi), the precursor to cobalamin (vitamin B(12)), to currently approved cyanide antidotes. Cbi has extremely high affinity for cyanide and substantial solubility in water.

Materials and methods

We studied Cbi in both an inhaled and intraperitoneal model of cyanide

SUBMITTER: Chan A 

PROVIDER: S-EPMC3119202 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature