Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.

ABSTRACT: Fibroblast growth factors (FGFs) and regulators of the FGF signalling pathway are expressed in several cell types within the cerebellum throughout its development. Although much is known about the function of this pathway during the establishment of the cerebellar territory during early embryogenesis, the role of this pathway during later developmental stages is still poorly understood. Here, we investigated the function of sprouty genes (Spry1, Spry2 and Spry4), which encode feedback antagonists of FGF signalling, during cerebellar development in the mouse. Simultaneous deletion of more than one of these genes resulted in a number of defects, including mediolateral expansion of the cerebellar vermis, reduced thickness of the granule cell layer and abnormal foliation. Analysis of cerebella

SUBMITTER: Yu T 

PROVIDER: S-EPMC3119305 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature