Ray: simultaneous assembly of reads from a mix of high-throughput sequencing technologies.

ABSTRACT: An accurate genome sequence of a desired species is now a pre-requisite for genome research. An important step in obtaining a high-quality genome sequence is to correctly assemble short reads into longer sequences accurately representing contiguous genomic regions. Current sequencing technologies continue to offer increases in throughput, and corresponding reductions in cost and time. Unfortunately, the benefit of obtaining a large number of reads is complicated by sequencing errors, with different biases being observed with each platform. Although software are available to assemble reads for each individual system, no procedure has been proposed for high-quality simultaneous assembly based on reads from a mix of different technologies. In this paper, we describe a parallel short-read asse

SUBMITTER: Boisvert S 

PROVIDER: S-EPMC3119603 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature