Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

ABSTRACT: Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours. Many clock proteins undergo circadian cycles of post-translational modifications. Among these modifications, protein phosphorylation plays an important role in regulating activity, stability and intracellular localization of clock components. Several protein kinases were characterized as regulators of the circadian clock. However, the function of protein phosphatases, which balance phosphorylation events, in the mammalian clock mechanism is less well understood. Here, we identify protein phosphatase 1 (PP1) as regulator of period and light-induced rese

SUBMITTER: Schmutz I 

PROVIDER: S-EPMC3119686 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature