Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study.

ABSTRACT:

Objective

To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study.

Research design and methods

SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with recently diagnosed diabetes. Using autoimmunity (at least one of two diabetes autoantibodies) and insulin sensitivity (equation validated against hyperinsulinemic-euglycemic clamps) as the main etiologic markers, we described four categories along a bidimensional spectrum: autoimmune plus insulin-sensitive (IS), autoimmune plus insulin-resistant (IR), nonautoimmune plus IS, and nonautoimmune plus IR. We then explored how characteristics, including genetic susce

SUBMITTER: Dabelea D 

PROVIDER: S-EPMC3120176 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature