Insulin detemir reduces weight gain as a result of reduced food intake in patients with type 1 diabetes.

ABSTRACT:

Objective

Insulin detemir lacks the usual propensity for insulin to cause weight gain. We investigated whether this effect was a result of reduced energy intake and/or increased energy expenditure.

Research design and methods

A 32-week, randomized crossover design trial was undertaken in 23 patients with type 1 diabetes. Patients on a basal-bolus regimen (with insulin aspart as the bolus insulin) were randomly assigned to insulin detemir or NPH insulin as a basal insulin for 16 weeks, followed by the other basal insulin for 16 weeks. At the end of each 16-week period, total energy expenditure, resting energy expenditure, diet-induced thermogenesis, activity energy expenditure, energy intake, weight change, glycemic control, hypoglycemic episodes, and hormones that affect sat

SUBMITTER: Zachariah S 

PROVIDER: S-EPMC3120205 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature