Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes.

ABSTRACT:

Background

The genome of Helicobacter pylori, an oncogenic bacterium in the human stomach, rapidly evolves and shows wide geographical divergence. The high incidence of stomach cancer in East Asia might be related to bacterial genotype. We used newly developed comparative methods to follow the evolution of East Asian H. pylori genomes using 20 complete genome sequences from Japanese, Korean, Amerind, European, and West African strains.

Results

A phylogenetic tree of concatenated well-defined core genes supported divergence of the East Asian lineage (hspEAsia; Japanese and Korean) from the European lineage ancestor, and then from the Amerind lineage ancestor. Phylogenetic profiling revealed a large difference in the repertoire of outer membrane proteins (including oipA, hopMN

SUBMITTER: Kawai M 

PROVIDER: S-EPMC3120642 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature