CASCADE_SCAN: mining signal transduction network from high-throughput data based on steepest descent method.

ABSTRACT:

Background

Signal transduction is an essential biological process involved in cell response to environment changes, by which extracellular signaling initiates intracellular signaling. Many computational methods have been generated in mining signal transduction networks with the increasing of high-throughput genomic and proteomic data. However, more effective means are still needed to understand the complex mechanisms of signaling pathways.

Results

We propose a new approach, namely CASCADE_SCAN, for mining signal transduction networks from high-throughput data based on the steepest descent method using indirect protein-protein interactions (PPIs). This method is useful for actual biological application since the given proteins utilized are no longer confined to membrane recep

SUBMITTER: Wang K 

PROVIDER: S-EPMC3120702 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature