Objective identification of residue ranges for the superposition of protein structures.

ABSTRACT:

Background

The automation of objectively selecting amino acid residue ranges for structure superpositions is important for meaningful and consistent protein structure analyses. So far there is no widely-used standard for choosing these residue ranges for experimentally determined protein structures, where the manual selection of residue ranges or the use of suboptimal criteria remain commonplace.

Results

We present an automated and objective method for finding amino acid residue ranges for the superposition and analysis of protein structures, in particular for structure bundles resulting from NMR structure calculations. The method is implemented in an algorithm, CYRANGE, that yields, without protein-specific parameter adjustment, appropriate residue ranges in most commonly o

SUBMITTER: Kirchner DK 

PROVIDER: S-EPMC3120703 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature