The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model.

ABSTRACT: A low-protein diet applied during pregnancy in the rat results in intrauterine growth restricted (IUGR) fetuses. In humans, IUGR is associated with increased perinatal morbidity, higher incidence of neuro-developmental defects and increased risk of adult metabolic anomalies, such as diabetes and cardiovascular disease. Development and function of many organs are affected by environmental conditions such as those inducing fetal and early postnatal growth restriction. This phenomenon, termed "fetal programming" has been studied unconnectedly in some organs, but very few studies (if any) have investigated at the same time several organs, on a more comparative basis. However, it is quite probable that IUGR affects differentially most organ systems, with possible persistent changes in gene expr

SUBMITTER: Vaiman D 

PROVIDER: S-EPMC3120850 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature