Combining disease models to test for gene-environment interaction in nuclear families.

ABSTRACT: It is useful to have robust gene-environment interaction tests that can utilize a variety of family structures in an efficient way. This article focuses on tests for gene-environment interaction in the presence of main genetic and environmental effects. The objective is to develop powerful tests that can combine trio data with parental genotypes and discordant sibships when parents' genotypes are missing. We first make a modest improvement on a method for discordant sibs (discordant on phenotype), but the approach does not allow one to use families when all offspring are affected, e.g., trios. We then make a modest improvement on a Mendelian transmission-based approach that is inefficient when discordant sibs are available, but can be applied to any nuclear family. Finally, we propose a hy

SUBMITTER: Hoffmann TJ 

PROVIDER: S-EPMC3120904 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature