Association between ITGA2 C807T polymorphism and gastric cancer risk.

ABSTRACT:

Aim

To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.

Methods

A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.

Results

The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals

SUBMITTER: Chen J 

PROVIDER: S-EPMC3120947 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature