Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.

ABSTRACT:

Objective

The severity of joint destruction in rheumatoid arthritis (RA) is highly variable from patient to patient and is influenced by genetic factors. Genome-wide association studies have enormously boosted the field of the genetics of RA susceptibility, but risk loci for RA severity remain poorly defined. A recent meta-analysis of genome-wide association studies identified 6 genetic regions for susceptibility to autoantibody-positive RA: CD40, KIF5A/PIP4K2C, CDK6, CCL21, PRKCQ, and MMEL1/TNFRSF14. The purpose of this study was to investigate whether these newly described genetic regions are associated with the rate of joint destruction.

Methods

RA patients enrolled in the Leiden Early Arthritis Clinic were studied (n=563). Yearly radiographs were scored using the Sharp/v

SUBMITTER: van der Linden MP 

PROVIDER: S-EPMC3121053 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature