The effects of magnesium pretreatment on reperfusion injury during living donor liver transplantation.

ABSTRACT:

Background

Ischemia reperfusion (IR) injury is a complex phenomenon that leads to organ dysfunction and causes primary liver failure following liver transplantation. We investigated whether an intravenous administration of magnesium before reperfusion can prevent or reduce IR injury.

Methods

Fifty-nine living donor liver transplant recipients were randomly assigned to an MG group (n = 31) or an NS group (n = 28). Each group was also divided in two groups based on the preoperative magnesium levels (normal: ≥ 0.70 mmol/L, low: < 0.70 mmol/L). The MG groups received 25 mg/kg of MgSO(4) mixed in 100 ml normal saline intravenously before reperfusion and the NS groups received an equal volume of normal saline. The levels of lactate, pH, arterial oxygen tension, and base excess wer

SUBMITTER: Kim JE 

PROVIDER: S-EPMC3121087 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature