Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California.

ABSTRACT: Although previous investigations have indicated a role for genetic factors in smoking initiation, the underlying genetic mechanisms are still unknown. In 2,339 adolescents from a Chinese Han population in the Wuhan Smoking Prevention Trial (Wuhan, China, 1998-1999), the authors explored the association of 57 genes in the dopamine pathway with smoking initiation. Using a conservative approach for declaring significance, positive findings were further examined in an independent sample of 603 Caucasian adolescents followed for up to 10 years as part of the Children's Health Study (Southern California, 1993-2009). The authors identified 1 single nucleotide polymorphism (rs2298122) in the calcyon neuron-specific vesicular protein gene (CALY) that was positively associated with smoking initiatio

SUBMITTER: Li D 

PROVIDER: S-EPMC3121219 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature