Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes.

ABSTRACT:

Objective

A better understanding of the molecular mechanisms underlying the development and progression of diabetic neuropathy (DN) is essential for the design of mechanism-based therapies. We examined changes in global gene expression to define pathways regulated by diabetes in peripheral nerve.

Research design and methods

Microarray data for 24-week-old BKS db/db and db/+ mouse sciatic nerve were analyzed to define significantly differentially expressed genes (DEGs); DEGs were further analyzed to identify regulated biological processes and pathways. Expression profile clustering was performed to identify coexpressed DEGs. A set of coexpressed lipid metabolism genes was used for promoter sequence analysis.

Results

Gene expression changes are consistent with structura

SUBMITTER: Pande M 

PROVIDER: S-EPMC3121428 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature