Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome.

ABSTRACT:

Objective

Comprehensive proteomic profiling of the human adipocyte secretome identified dipeptidyl peptidase 4 (DPP4) as a novel adipokine. This study assessed the functional implications of the adipokine DPP4 and its association to the metabolic syndrome.

Research design and methods

Human adipocytes and skeletal and smooth muscle cells were used to monitor DPP4 release and assess the effects of soluble DPP4 on insulin signaling. In lean and obese subjects, depot-specific expression of DPP4 and its release from adipose tissue explants were determined and correlated to parameters of the metabolic syndrome.

Results

Fully differentiated adipocytes exhibit a substantially higher release of DPP4 compared with preadipocytes or macrophages. Direct addition of DPP4 to fat and

SUBMITTER: Lamers D 

PROVIDER: S-EPMC3121429 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature