Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration.

ABSTRACT:

Background

Syndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes. Our recent publications have demonstrated that syndecan-1 translocates into the nucleus and hampers tumor cell proliferation. In the present study, we aimed to investigate the role of syndecan-1 in tumor cell adhesion and migration, with special focus on the importance of its distinct protein domains, to better understand the structure-function relationship of syndecan-1 in tumor progression.

Methodology/principal findings

We utilized two mesenchymal tumor cell lines which were transfected to stably overexpress full-length

SUBMITTER: Zong F 

PROVIDER: S-EPMC3121713 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature