Single cell time-resolved quorum responses reveal dependence on cell density and configuration.

ABSTRACT: Bacterial communication via quorum sensing has been extensively investigated in recent years. Bacteria communicate in a complex manner through the production, release, and reception of diffusible low molecular weight chemical signaling molecules. Much work has focused on understanding the basic mechanisms of quorum sensing. As more and more bacteria grow resistant to conventional antibiotics, the development of drugs that do not kill bacteria but instead interrupt their communication is of increasing interest. This study presents a method for analyzing bacterial communication by investigating single cell responses. Most conventional analysis methods for bacterial communication are based on the averaged response from many bacteria, masking how individual cells respond to their immediate env

SUBMITTER: Whitaker RD 

PROVIDER: S-EPMC3122220 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature